Further record year of biologics sales in 2018 due to innovative antibodies

STUTTGART, Germany I April 4, 2018 I 2018 was another record year for global sales of branded recombinant therapeutic antibodies and proteins: US$ 202 mln (+7.3% vs previous year). Major contributing factor to the growth were sales of therapeutic antibodies which showed a continuous annual growth rate (CAGR) of 14.1% over the last seven years. […]

TCR Engineered T-Cells are coming out of the shadows and into the light

The next two years will give definitive clues about the prospects of this promising treatment modality for solid tumors STUTTGART, Germany I May 23, 2018 I T-Cell Receptors (TCR) and Chimeric Antigen Receptors (CAR) are the cuttingedge of adoptive T-cell therapy. Both receptors deploy T-cells to target the tumor, but CAR T-cells (CAR-T) are limited […]

Druggability of intracellular targets: a challenging, but highly rewarded goal for emerging technologies to generate TCR fusion proteins, TCRL antibodies and cell-penetrating biologics

STUTTGART, Germany I January 25, 2018 I A tissue-based map of the human proteome suggests that about 75 % are intracellular or secreted targets not accessible for conventional monoclonal antibody and chimeric antigen receptor (CAR) T-cell therapy (Uhlen et al., Science, 2015). Thus, the large pool of intracellular protein targets, including overexpressed oncogenic proteins, mutated […]

Oncolytic Viruses: a still undervalued technology with strong growth perspectives

STUTTGART, Germany I January 25, 2017 I The acquisition of oncolytic virus company BioVex by Amgen in late 2011 for up to US$ 1 bln has been a game changer for the field of oncolytic viruses, now recognized as a promising new therapeutic approach for cancer treatment. The approval of Amgen‘s herpes simplex oncolytic virus […]